ea0025p244 | Pituitary | SFEBES2011
Awais Raheela
, McNamara Anne
, Harper Claire
, Adamson Anthony
, Spiller Dave
, Semprini Sabrina
, Mullins John
, Davis Julian
, White Michael R H
Alternative promoters control many genes including prolactin (PRL), which in man is expressed at extra-pituitary sites controlled by an alternative promoter located 5.8 Kbp upstream of the pituitary transcription start site. Previous studies using short promoter fragments may be misleading, as the human hPRL genomic locus has many conserved far-upstream regions. To study the function of the alternative promoter, we engineered a bacterial artificial chromosome (BAC) expressing ...